Antitumoral effects of Santolina chameacyparissus on Non-Small Cell Lung Cancer Cells

Santolina chameacyparissus (Santo) is an evergreen plant which traditionally used for its anti-inflammatory effects in various diseases. In this study, we aimed to explore the of Santo non-small cell lung cancer cells. We extracted volatile oil from and evaluated cytotoxicity, apoptosis, motility extract on two (NSCLC) lines; one a patient derived other commercially available A549 also identified components via GC/MS investigated possible targets major using qPCR docking studies. Cytotoxicity tests showed dose dependent killing activity flow cytometry assays exposed apoptotic Santo. The essential remarkably decreased migration rate cells, therefore expression levels epithelial mesenchymal transition related genes E-cadherin Vimentin ratio, ZEB1 SNAIL another gene Ezrin. did not change EMT but Ezrin levels. According results GS/MS analysis, Artemisia ketone Camphor were as molecules extract. Docking analysis revealed that artemisia ketone, component extract, potentially strong binding active site ezrin protein both camphor had ability bind DNA. present study indicate are promising anti-cancer agents, their potential targeting DNA oncogenic proteins cells seems worth focus drug discovery science.